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Table 12 Top canonical pathways affected by down-regulated genes/isoforms in rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

  Down-regulated genes  
Canonical Pathway p-value Ratio
LXR/RXR Activation 0.011 0.057
Atherosclerosis Signaling 0.011 0.057
LPS/IL-1 Mediated Inhibition of RXR Function 0.017 0.044
Inhibition of Angiogenesis by TSP1 0.018 0.083
Phenylalanine Metabolism 0.019 0.086
  Down-regulated Isoforms  
Canonical Pathway p-value Ratio
Role of BRCA1 in DNA Damage Response 0.002 0.125
Mitotic Roles of Polo-Like Kinase 0.002 0.123
Cardiac β-adrenergic Signaling 0.004 0.079
Type I Diabetes Mellitus Signaling 0.005 0.086
Graft-versus-Host Disease Signaling 0.007 0.125
  1. Top canonical pathways significantly affected in RASFs compared to SFs as determined by Ingenuity Pathway Analysis. Pathways with a p-value less than 0.05 defined as significant.