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Table 11 Top canonical pathways affected by up-regulated genes/isoforms in rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

  Up-regulated genes  
Canonical Pathway p-value Ratio
Antigen Presentation Pathway 0.000 0.455
Graft-versus-Host Disease Signaling 0.000 0.275
Communication between Innate and Adaptive Immune Cells 0.000 0.188
Crosstalk between Dendritic Cells and Natural Killer Cells 0.000 0.159
Autoimmune Thyroid Disease Signaling 0.000 0.214
  Up-regulated Isoforms  
Canonical Pathway p-value Ratio
Atherosclerosis Signaling 0.001 0.133
Hepatic Fibrosis / Hepatic Stellate Cell Activation 0.001 0.119
Colorectal Cancer Metastasis Signaling 0.010 0.088
Toll-like Receptor Signaling 0.011 0.143
FXR/RXR Activation 0.012 0.114
  1. Top canonical pathways significantly affected in RASFs compared to SFs as determined by Ingenuity Pathway Analysis. Pathways with a p-value less than 0.05 defined as significant.