RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

Cell & Bioscience

Table 10 Top networks affected by down-regulated genes/isoforms in rheumatoid arthritis synovial RNA

	Down-regulated genes
Top Functions	Score	Genes
Cellular Movement, Cell Death, Tissue Development	35	32
Cellular Growth and Proliferation, Cellular Development, Hematological System Development and Function	29	28
Cell Cycle, Cellular Growth and Proliferation, Cell Death	27	27
Cellular Growth and Proliferation, Cell Cycle, Tissue Development	23	24
Hematological System Development and Function, Tissue Morphology, Tissue Development	21	23
	Down-Regulated Isoforms
Top Functions	Score	Genes
Cellular Growth and Proliferation, Cell Death, Cellular Movement	45	43
DNA Replication, Recombination, and Repair, Cell Cycle, Hematological System Development and Function	28	32
Cellular Development, Cell Morphology, Cellular Assembly and Organization	25	30
Cellular Growth and Proliferation, Tissue Morphology, Hematological System Development and Function	25	30
Cellular Growth and Proliferation, Cellular Movement, Embryonic Development	24	29
Cell Death, Cellular Development, Hematological System Development and Function	24	29

Networks significantly affected in RASFs compared to control SFs as determined by Ingenuity Pathway Analysis. The score is based on the p-value of the affected network. Networks with a score of 15 or greater were defined as significant.

ISSN: 2045-3701