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Table 10 Top networks affected by down-regulated genes/isoforms in rheumatoid arthritis synovial RNA

From: RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis

  Down-regulated genes
Top Functions Score Genes
Cellular Movement, Cell Death, Tissue Development 35 32
Cellular Growth and Proliferation, Cellular Development, Hematological System Development and Function 29 28
Cell Cycle, Cellular Growth and Proliferation, Cell Death 27 27
Cellular Growth and Proliferation, Cell Cycle, Tissue Development 23 24
Hematological System Development and Function, Tissue Morphology, Tissue Development 21 23
  Down-Regulated Isoforms
Top Functions Score Genes
Cellular Growth and Proliferation, Cell Death, Cellular Movement 45 43
DNA Replication, Recombination, and Repair, Cell Cycle, Hematological System Development and Function 28 32
Cellular Development, Cell Morphology, Cellular Assembly and Organization 25 30
Cellular Growth and Proliferation, Tissue Morphology, Hematological System Development and Function 25 30
Cellular Growth and Proliferation, Cellular Movement, Embryonic Development 24 29
Cell Death, Cellular Development, Hematological System Development and Function 24 29
  1. Networks significantly affected in RASFs compared to control SFs as determined by Ingenuity Pathway Analysis. The score is based on the p-value of the affected network. Networks with a score of 15 or greater were defined as significant.