Figure 8
From: The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
A cartoon illustrating how oxygen may affect SWI/SNF composition and function. In normoxic cells, the components form the SWI/SNF complex in the nucleus, enabling it to remodel chromatin at the target genes. In hypoxic cells, Swi3 and five other components are retained in the cytosol, perhaps due to modifications of these components and/or interactions with unidentified factor(s) X. In the nucleus, Swi2 and other remaining components may interact with some other proteins (marked as A, B, and C), forming complexes with different composition and targeting different sets of genes.