Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX

Table 1 Mean size (μm) of DIG-dUTP incorporation signals in nuclei of hamster and mouse cells in the presence or absence of Tax or etoposide

Experimental groups		n	mean size	Standard deviation
1	Mouse embryo fibroblasts (MEFs)	68	1.37	0.46
2	MEFs + etoposide 5 μg/ml *	46	1.77	1.15
3	MEFs + etoposide 10 μg/ml *	50	2.06	0.96
4	CHO	66	1.16	0,31
5	CHO + Tax	50	3.81	1.74
6	xrs-6	56	1.99	0.82
7	xrs-6 + Tax	120	2.08	0.67
8	PKcs+/+	38	1.43	0.51
9	PKcs+/+ + Tax	70	2.28	1.05
10	PKcs−/−	98	1.35	0.45
11	PKcs−/− + Tax	150	2.35	0.99
12	XRCC4+/+	77	1.63	0.69
13	XRCC4+/+ + Tax	50	3.53	1.68
14	XRCC4−/−	175	1.74	0.67
15	XRCC4−/− + Tax	48	3.39	1.12
16	H2AX+/+	68	1.37	0.46
17	H2AX+/+ + Tax	70	2.50	0.95
18	H2AX−/−	65	2.01	0.76
19	H2AX−/− + Tax	68	3.20	0.90