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Table 1 Mean size (μm) of DIG-dUTP incorporation signals in nuclei of hamster and mouse cells in the presence or absence of Tax or etoposide

From: Unstabilized DNA breaks in HTLV-1 Tax expressing cells correlate with functional targeting of Ku80, not PKcs, XRCC4, or H2AX

Experimental groups

n

mean size

Standard deviation

1

Mouse embryo fibroblasts (MEFs)

68

1.37

0.46

2

MEFs + etoposide 5 μg/ml *

46

1.77

1.15

3

MEFs + etoposide 10 μg/ml *

50

2.06

0.96

4

CHO

66

1.16

0,31

5

CHO + Tax

50

3.81

1.74

6

xrs-6

56

1.99

0.82

7

xrs-6 + Tax

120

2.08

0.67

8

PKcs+/+

38

1.43

0.51

9

PKcs+/+ + Tax

70

2.28

1.05

10

PKcs−/−

98

1.35

0.45

11

PKcs−/− + Tax

150

2.35

0.99

12

XRCC4+/+

77

1.63

0.69

13

XRCC4+/+ + Tax

50

3.53

1.68

14

XRCC4−/−

175

1.74

0.67

15

XRCC4−/− + Tax

48

3.39

1.12

16

H2AX+/+

68

1.37

0.46

17

H2AX+/+ + Tax

70

2.50

0.95

18

H2AX−/−

65

2.01

0.76

19

H2AX−/− + Tax

68

3.20

0.90

  1. * = three hours of treatment.
  2. n = number of measured DIG-dUTP incorporation signals.