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Table 1 Existence of EGFR family receptors in the nucleus

From: Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family

EGFR family receptor Type Size (kDa) Cell/Tissue detection Reference
EGFR Full-length 170 hepatocyte, breast, pancreatic, head and neck, glioblastoma, lung, and skin cancers, etc. [12, 14, 22, 28, 30, 38, 39, 49]
EGFRvIII In-frame deletion 145 normal glial cells, glioblastoma, prostate cancer [26, 30, 65]
EGFR variant mLEEK In-frame splice 45 glioblastoma [16]
ErbB-2: p185ErbB-2 Full-length 185 breast cancer [29, 68, 110]
ErbB-2: p95ErbB-2 N-terminal truncation 95 breast cancer [69, 70]
ErbB-3 Full-length 185 nonmalignant epithelial cells, breast cancer, prostate cancer [24, 65, 71, 72]
ErbB-4 Full-length 180 normal cells: brain cells, endothelial cells [74, 75]
ErbB-4 ICD N-terminal truncation 80 breast cancer, prostate cancer, embryonic brain [20, 65, 73, 76]