Table 1 Existence of EGFR family receptors in the nucleus

EGFR

Full-length

170

hepatocyte, breast, pancreatic, head and neck, glioblastoma, lung, and skin cancers, etc.

[12, 14, 22, 28, 30, 38, 39, 49]

EGFRvIII

In-frame deletion

145

normal glial cells, glioblastoma, prostate cancer

[26, 30, 65]

EGFR variant mLEEK

In-frame splice

45

glioblastoma

[16]

ErbB-2: p185^ErbB-2

Full-length

185

breast cancer

[29, 68, 110]

ErbB-2: p95^ErbB-2

N-terminal truncation

95

breast cancer

[69, 70]

ErbB-3

Full-length

185

nonmalignant epithelial cells, breast cancer, prostate cancer

[24, 65, 71, 72]

ErbB-4

Full-length

180

normal cells: brain cells, endothelial cells

[74, 75]

ErbB-4 ICD

N-terminal truncation

80

breast cancer, prostate cancer, embryonic brain

[20, 65, 73, 76]