Transcriptional features and the G-quadruplex binding model of EWS. (A) Structural features of EWS. EAD: EWS activation domain, RGG: Arg-Gly-Gly domain, RRM: RNA recognition motif, Znf: zinc finger. (B) Mechanism of RNA binding domain-dependent transcriptional regulation of EWS. DBD: GAL4 DNA binding domain. (C) The G-quadruplex binding model by EWS RBD containing RGG domain.