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Figure 1 | Cell & Bioscience

Figure 1

From: Roles of TGFβ signaling Smads in squamous cell carcinoma

Figure 1

Schematic of Smads mediated TGFβ signaling pathway. TGFβ ligand binds to TGFβRII/TGFβRI receptors leading to phosphorylation of Smad2/3. Phosphorylated Smad2/3 binds to Smad4 to form a protein complex that undergoes nuclear translocation and regulates the expression of TGFβ target genes through binding to the Smad-binding element (SBE).

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