The replication of chimeric NL4-3 miRNA viruses in cultured Jurkat T-cells. Jurkat T-cells were infected with NL4-3, NL4-3 let7 scr, NL4-3 let7a, NL4-3 miR211 or NL4-3 miR326 as normalized by infectious units. Cell culture supernatants were sampled at days 2, 4, 6 and 8 post infection, and viral replication was determined by RT assay. Results shown are the averages of three independent infections per clone. * indicates a p-value < 0.01 and ** indicates a p-value < 0.01 as compared to NL4-3 let7 scr.