Figure 2
From: Epithelial-Mesenchymal Transition in tumor microenvironment
Signaling pathways that regulate Epithelial-Mesenchymal Transition (EMT) in tumor microenvironment. EMT is described as a multi-step event that epithelial cells lose numerous epithelial characteristics to assume properties of mesenchymal cells, and the inducers of EMT are complex in tumor microenvironment. Therefore, EMT-related signaling pathways are various, including TGF-β, NF-κB, Wnt, Notch, and others.