Structure of core domain of human TBP bound to the TATA element of the adenovirus major late promoter. The DNA is shown in grey, TBP is shown in red. Amino acids that are different between TBP and TBP2 are shown in blue. Left: Frontal view, showing that all amino acids contacting the DNA are identical between TBP and TBP2 (red). Substituted amino acids are solvent exposed (blue). Right: Top view, showing that TBP aligns with the minor groove in which it is inserted.