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Table 12 CDSs related to tolerance of oxidative stress in L. hongkongensis, C. violaceum, N. meningitidis and N. gonorrhoeae.

From: Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome-wide analysis

Role Gene Protein Regulated by L. hongkongensis HLHK9 C. violaceum ATCC12472 N. meningitidis MC58 N. gonorrhoeae
FA1090
Transcriptional regulator
   soxR SoxR H2O2, O2 - CV2793 - -
   soxS SoxS SoxR - - - -
   oxyR OxyR H2O2 LHK_02531 CV3378 NMB0173 NGO1813
   ohrR Organic hydroperoxide resistance transcriptional regulator Organic peroxides - CV0210 - -
   fnr Fumarate/nitrate reductase regulator O2 LHK_00352 CV3647 NMB0380 NGO1579
   perR PerR H2O2 - - NMB1266 NGO0542
   lrp Leucine-responsive protein Leucine LHK_01860 CV1913 NMB0573
NMB1650
NGO1294
NGO1407
Oxidant-resistant dehydratase isozymes
   fumC Fumarase C SoxRS, RpoS, FNR LHK_00495 CV1120 NMB1458 NGO1029
   acnA Aconitase A SoxRS, FNR, Fur, RpoS LHK_02153
LHK_02309
CV1121
CV2054
NMB0433 -
Superoxide scavenging
   sodA Manganese superoxide dismutase SoxRS, FNR - - - -
   sodB Iron superoxide dismutase   LHK_01716 CV0867
CV2504
NMB0884 NGO0405
   sodC Copper-zinc superoxide dismutase H2O2, RpoS, FNR - - NMB1398 -
Hydrogen peroxide scavenging
   ahpC Alky hydroperoxide reductase OxyR, PerR LHK_00938 CV3739 - -
   ahpF Alky hydroperoxide reductase OxyR, PerR - - - -
   cpx Cytochrome c peroxidase FNR LHK_02666 CV0300 - NGO1769
catalase/
peroxidase
Hydroperoxidase I OxyR, RpoS LHK_01300
LHK_02436
- - -
   catalase Hydroperoxidase II H2O2, RpoS LHK_01264 CV3549 NMB0216 NGO1767
Exclusion and export of redox-cycling antibiotics
   micF Antisense RNA to porin OmpF SoxRS, Lrp, OmpR - - - -
   acrA-acrB-tolC Drug export system SoxRS LHK_01426-LHK_01425-LHK_01424 CV0435-CV0434-CV0433 NMB1716-NMB1715-NMB1714 NGO1365-NGO1364-NGO1363
     LHK_02129-LHK_02130-LHK_02131 CV2240-CV2241-CV2242   
     LHK_02929-LHK_02930-LHK_02931    
Redox balancing
   nfnB Nitroreductase SoxRS LHK_01953
LHK_03211
CV2244 NMB0804 NGO0388
DNA repair
   xthA Exodeoxyribonuclease III H2O2, RpoS LHK_02447 CV0877 NMB0399 NGO1561
   nth Endonuclease III   LHK_01218 CV3293 NMB0533 NGO0139
   nfo Endonuclease IV SoxRS - - - -
   mutM Formamidopyrimidine-DNA glycosylase FNR LHK_00316 CV4062 NMB1295 NGO0610
   mutY Adenine glycosylase   LHK_02781 CV3703 NMB1396 NGO0710
   mutT 7,8-dihydro-8-oxoguanine triphosphatase   LHK_02262 CV1787 NMB1064 -
   mutT homologues MutT/NUDIX family protein   LHK_00322 CV0032 NMB0453 NGO1506
     LHK_00604 CV1112   
     LHK_01693 CV1586   
     LHK_01823 CV1767   
      CV3401   
      CV3611   
Protein repair
   msrAB Protein-methionine-S-oxide reductase   LHK_01369 (msrB) CV2325 (msrA)
CV3212 (msrB)
NMB0044 (msrAB) NGO2059 (msrAB)
Reduction of disulfide bonds
   trxA Thioredoxin 1 ppGpp LHK_01690 CV1584 NMB1366 NGO0652
   - Thioredoxin   LHK_00591 CV1325 NMB0006 NGO0057
     LHK_01462 CV4257 NMB1845 NGO1923
     LHK_01491 CV4279 NMB1958 NGO2124
     LHK_02476    
     LHK_02092    
   trxC Thioredoxin 2 OxyR - CV1106 - -
   trxB Thioredoxin reductase   LHK_1482 CV1895
CV2813
NMB1324 NGO0580
   - Peroxiredoxin   LHK_02841 CV3708 NMB0946 NGO0926
   gpxA Glutathione peroxidase   LHK_00424 CV1107
CV3555
CV3787
NMB1621 -
   gshA Glutamate-cysteine ligase   LHK_03085 CV4276 NMB1037 NGO0608
   gshB Glutathione synthase   LHK_03093 CV4275 NMB1559 NGO1217
   grxA Glutaredoxin 1 OxyR LHK_00503 CV3620 NMB0773 NGO0351
   grxB Glutaredoxin 2 RpoS, ppGpp - - NMB1734 NGO1381
   grxC Glutaredoxin 3   LHK_02837 CV1126 NMB1790 NGO0114
   gor Glutathione reductase OxyR, RpoS, ppGpp LHK_01492 CV2037 NMB0947 NGO0925
Reduction of iron-sulfur clusters
   fpr NADPH-ferredoxin reductase SoxRS LHK_02993 CV0086
CV4045
NMB1044
NMB1450
NGO0687
NGO0734
   fldA Flavodoxin SoxRS - - - -
   fldB Flavodoxin SoxRS - - - -
   yggX Iron trafficking protein SoxRS LHK_00654 CV3356 NMB2021 NGO2083
Organic hydroperoxide resistance
   ohrA Organic hydroperoxide resistance protein OhrR - CV0209 - -
   ohrB Hydrogenperoxide resistance protein Sigma B - CV2493 - -
Disulfide bond formation in periplasm
   dsbA Disulfide oxidoreductases Cpx two component system LHK_02939 CV3998 NMB0278
NMB0294
NMB0407
NGO1548
NGO1717
   dsbB Oxidoreductase   LHK_01744 CV3193 NMB1649 NGO1292
   dsbG Thiol:disulfide interchange protein OxyR - CV2637 - -
Increase cellular pools of reduced pyridine nucleotides for glutathione-dependent repair reactions
   zwf Glucose-6-phosphate 1-dehydrogenase SoxRS LHK_01919 CV0145 NMB1392 NGO0715
Limit iron availability
   bfr Bacterioferritin Fur LHK_01239 CV3399
CV3552
NMB1206
NMB1207
NGO0794
NGO0795
   dps DNA-binding protein OxyR, RpoS LHK_01835
LHK_03179
CV4253 - -
   fur Ferric uptake regulator PerR, OxyR, SoxRS LHK_01431 CV1797 NMB0205 NGO1779
Protein binding
   hslO Molecular chaperone Hsp33 H2O2 & temperature LHK_02184 CV2000 NMB2000 NGO1189
Others
   rimK Ribosomal protein S6 modification protein SoxRS - - - -
   ribA Cyclic GMP hydrolase SoxRS LHK_02390 CV2005 NMB1254 NGO1134