Table 12 CDSs related to tolerance of oxidative stress in L. hongkongensis, C. violaceum, N. meningitidis and N. gonorrhoeae.

Transcriptional regulator

   soxR

SoxR

H₂O₂, O₂

-

CV2793

-

-

   soxS

SoxS

SoxR

-

-

-

-

   oxyR

OxyR

H₂O₂

LHK_02531

CV3378

NMB0173

NGO1813

   ohrR

Organic hydroperoxide resistance transcriptional regulator

Organic peroxides

-

CV0210

-

-

   fnr

Fumarate/nitrate reductase regulator

O₂

LHK_00352

CV3647

NMB0380

NGO1579

   perR

PerR

H₂O₂

-

-

NMB1266

NGO0542

   lrp

Leucine-responsive protein

Leucine

LHK_01860

CV1913

NMB0573

NMB1650

NGO1294

NGO1407

Oxidant-resistant dehydratase isozymes

   fumC

Fumarase C

SoxRS, RpoS, FNR

LHK_00495

CV1120

NMB1458

NGO1029

   acnA

Aconitase A

SoxRS, FNR, Fur, RpoS

LHK_02153

LHK_02309

CV1121

CV2054

NMB0433

-

Superoxide scavenging

   sodA

Manganese superoxide dismutase

SoxRS, FNR

-

-

-

-

   sodB

Iron superoxide dismutase

LHK_01716

CV0867

CV2504

NMB0884

NGO0405

   sodC

Copper-zinc superoxide dismutase

H₂O₂, RpoS, FNR

-

-

NMB1398

-

Hydrogen peroxide scavenging

   ahpC

Alky hydroperoxide reductase

OxyR, PerR

LHK_00938

CV3739

-

-

   ahpF

Alky hydroperoxide reductase

OxyR, PerR

-

-

-

-

   cpx

Cytochrome c peroxidase

FNR

LHK_02666

CV0300

-

NGO1769

catalase/

peroxidase

Hydroperoxidase I

OxyR, RpoS

LHK_01300

LHK_02436

-

-

-

   catalase

Hydroperoxidase II

H₂O₂, RpoS

LHK_01264

CV3549

NMB0216

NGO1767

Exclusion and export of redox-cycling antibiotics

   micF

Antisense RNA to porin OmpF

SoxRS, Lrp, OmpR

-

-

-

-

   acrA-acrB-tolC

Drug export system

SoxRS

LHK_01426-LHK_01425-LHK_01424

CV0435-CV0434-CV0433

NMB1716-NMB1715-NMB1714

NGO1365-NGO1364-NGO1363

LHK_02129-LHK_02130-LHK_02131

CV2240-CV2241-CV2242

LHK_02929-LHK_02930-LHK_02931

Redox balancing

   nfnB

Nitroreductase

SoxRS

LHK_01953

LHK_03211

CV2244

NMB0804

NGO0388

DNA repair

   xthA

Exodeoxyribonuclease III

H₂O₂, RpoS

LHK_02447

CV0877

NMB0399

NGO1561

   nth

Endonuclease III

LHK_01218

CV3293

NMB0533

NGO0139

   nfo

Endonuclease IV

SoxRS

-

-

-

-

   mutM

Formamidopyrimidine-DNA glycosylase

FNR

LHK_00316

CV4062

NMB1295

NGO0610

   mutY

Adenine glycosylase

LHK_02781

CV3703

NMB1396

NGO0710

   mutT

7,8-dihydro-8-oxoguanine triphosphatase

LHK_02262

CV1787

NMB1064

-

   mutT homologues

MutT/NUDIX family protein

LHK_00322

CV0032

NMB0453

NGO1506

LHK_00604

CV1112

LHK_01693

CV1586

LHK_01823

CV1767

CV3401

CV3611

Protein repair

   msrAB

Protein-methionine-S-oxide reductase

LHK_01369 (msrB)

CV2325 (msrA)

CV3212 (msrB)

NMB0044 (msrAB)

NGO2059 (msrAB)

Reduction of disulfide bonds

   trxA

Thioredoxin 1

ppGpp

LHK_01690

CV1584

NMB1366

NGO0652

   -

Thioredoxin

LHK_00591

CV1325

NMB0006

NGO0057

LHK_01462

CV4257

NMB1845

NGO1923

LHK_01491

CV4279

NMB1958

NGO2124

LHK_02476

LHK_02092

   trxC

Thioredoxin 2

OxyR

-

CV1106

-

-

   trxB

Thioredoxin reductase

LHK_1482

CV1895

CV2813

NMB1324

NGO0580

   -

Peroxiredoxin

LHK_02841

CV3708

NMB0946

NGO0926

   gpxA

Glutathione peroxidase

LHK_00424

CV1107

CV3555

CV3787

NMB1621

-

   gshA

Glutamate-cysteine ligase

LHK_03085

CV4276

NMB1037

NGO0608

   gshB

Glutathione synthase

LHK_03093

CV4275

NMB1559

NGO1217

   grxA

Glutaredoxin 1

OxyR

LHK_00503

CV3620

NMB0773

NGO0351

   grxB

Glutaredoxin 2

RpoS, ppGpp

-

-

NMB1734

NGO1381

   grxC

Glutaredoxin 3

LHK_02837

CV1126

NMB1790

NGO0114

   gor

Glutathione reductase

OxyR, RpoS, ppGpp

LHK_01492

CV2037

NMB0947

NGO0925

Reduction of iron-sulfur clusters

   fpr

NADPH-ferredoxin reductase

SoxRS

LHK_02993

CV0086

CV4045

NMB1044

NMB1450

NGO0687

NGO0734

   fldA

Flavodoxin

SoxRS

-

-

-

-

   fldB

Flavodoxin

SoxRS

-

-

-

-

   yggX

Iron trafficking protein

SoxRS

LHK_00654

CV3356

NMB2021

NGO2083

Organic hydroperoxide resistance

   ohrA

Organic hydroperoxide resistance protein

OhrR

-

CV0209

-

-

   ohrB

Hydrogenperoxide resistance protein

Sigma B

-

CV2493

-

-

Disulfide bond formation in periplasm

   dsbA

Disulfide oxidoreductases

Cpx two component system

LHK_02939

CV3998

NMB0278

NMB0294

NMB0407

NGO1548

NGO1717

   dsbB

Oxidoreductase

LHK_01744

CV3193

NMB1649

NGO1292

   dsbG

Thiol:disulfide interchange protein

OxyR

-

CV2637

-

-

Increase cellular pools of reduced pyridine nucleotides for glutathione-dependent repair reactions

   zwf

Glucose-6-phosphate 1-dehydrogenase

SoxRS

LHK_01919

CV0145

NMB1392

NGO0715

Limit iron availability

   bfr

Bacterioferritin

Fur

LHK_01239

CV3399

CV3552

NMB1206

NMB1207

NGO0794

NGO0795

   dps

DNA-binding protein

OxyR, RpoS

LHK_01835

LHK_03179

CV4253

-

-

   fur

Ferric uptake regulator

PerR, OxyR, SoxRS

LHK_01431

CV1797

NMB0205

NGO1779

Protein binding

   hslO

Molecular chaperone Hsp33

H₂O₂ & temperature

LHK_02184

CV2000

NMB2000

NGO1189

Others

   rimK

Ribosomal protein S6 modification protein

SoxRS

-

-

-

-

   ribA

Cyclic GMP hydrolase

SoxRS

LHK_02390

CV2005

NMB1254

NGO1134