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Figure 5 | Cell & Bioscience

Figure 5

From: 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

Figure 5

17-DMAG treatment inhibits hemorrhage-induced caspase-3 activation. Mice were treated with 10 mg/kg 17-DMAG 16 hr prior to hemorrhage. After hemorrhage mice were allowed to respond for 6 hr before sample collection (n = 4-5 per group). (A) Representative gel shown. (B) Densitometric quantitation of active caspase-3 protein bands in panel A. *P < 0.05 vs. VEH, 17-D, and 17-D+HE. (C) Corresponding caspase-3 enzymatic activity. *P < 0.05 vs. VEH, 17-D, and 17-D+HE. VEH: vehicle; HE: hemorrhage; 17-D: 17-DMAG

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