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Figure 4 | Cell & Bioscience

Figure 4

From: 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

Figure 4

17-DMAG treatment inhibits hemorrhage-induced increases in NO, lipid peroxidation, ATP depletion, and cytokines. Mice were treated with 10 mg/kg 17-DMAG 16 hr prior to hemorrhage. After hemorrhage mice were allowed to respond for 6 hr before sample collection (n = 4-5 per group). Panels indicate levels measured as described in Methods: NO (A), MDA (B), cellular ATP (C), TNF-α (D), and IL-10 (E). For panels A, B, and E: *P < 0.05 vs. VEH, 17-D, and 17-D+HE. For panel C: *P < 0.05 vs. VEH, 17-D, and 17-D+HE; **P < 0.05 vs. VEH, VEH+HE, 17-D+HE; ***P < 0.05 vs. VEH, VEH+HE, and 17-D. VEH: vehicle; HE: hemorrhage; 17-D: 17-DMAG

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