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Figure 2 | Cell & Bioscience

Figure 2

From: 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

Figure 2

17-DMAG treatment inhibits hemorrhage-induced increases in iNOS and KLF6 and decrease in KLF4. Mice were treated with 10 mg/kg 17-DMAG 16 hr prior to hemorrhage. After hemorrhage mice were allowed to respond for 6 hr before sample collection (n = 4-5 per group). (A) Representative gel shown. (B) Densitometric quantitation of iNOS protein bands in panel A. *P < 0.05 vs. VEH, 17-D, and 17-D+HE. (C) Densitometric quantitation of KLF4 protein bands in panel A. *P < 0.05 vs. VEH, 17-D, and 17-D+HE; **P < 0.05 vs. VEH, VEH+HE, and 17-D+HE; ***P < 0.05 vs. VEH, VEH+HE, and 17-D. (D) Densitometric quantitation of KLF6 protein bands in panel A. *P < 0.05 vs. VEH, 17-D, and 17-D+HE; **P < 0.05 vs. VEH, VEH+HE, and 17-D. VEH: vehicle; HE: hemorrhage; 17-D: 17-DMAG

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