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Figure 1 | Cell & Bioscience

Figure 1

From: 17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

Figure 1

17-DMAG treatment increases HSP-70. (A) 17-DMAG structure. (B) Mice were treated with various doses of 17-DMAG 16 hr prior to sham hemorrhage. After sham hemorrhage mice were allowed to respond for 6 hr before sample collection. Representative gel shown. (C) Dose-response curve for various doses of 17-DMAG and HSP-70 (n = 5 per group). Estimated median effective dose is 10 ± 1 μg/g, calculated by Prism program 3.0. (D) Mice were treated with vehicle or 17-DMAG at 10 mg/kg 16 hr prior to hemorrhage. After hemorrhaged mice and sham mice were allowed to respond for 6 hr before sample collection. (n = 5 per group). Representative gel shown. (E) Densitometric quantitation of HSP70 protein bands in panel C. *P < 0.05 vs. VEH and 17-D; **P < 0.05 vs. VEH, VEH+HE, and 17-D+HE. VEH: vehicle; HE: hemorrhage; 17-D: 17-DMAG

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