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Table 3 CDSs related to multidrug resistance in L. hongkongensis

From: Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis

CDS Gene Product Organism with the closest matching sequence E-value Identities No. of TMSa Remarksb
LHK_00138 tolC TolC family type I secretion outer membrane protein Polaromonas naphthalenivorans 2e-72 203/455 (44%) -- OMP
LHK_00140 acrB Acriflavin resistance protein P. naphthalenivorans 0 723/1066 (67%) 13 RND
LHK_00141 acrA Efflux transporter, RND family, MFP subunit P. naphthalenivorans 2e-51 153/355 (43%) -- MFP
LHK_00142 arsR Transcription regulator ArsR Bordetella parapertussis 2e-26 62/99 (62%) -- TR
LHK_00221   RND efflux system outer membrane lipoprotein Pelobacter propionicus 1e-108 207/424 (48%) -- OMP
LHK_00222 macB Macrolide-specific ABC-type efflux carrier Bordetella avium 0 429/655 (65%) 4 ABC
LHK_00223 macA Efflux transporter, RND family, MFP subunit Lutiella nitroferrum 4e-127 252/384 (65%) -- MFP
LHK_00466   Hypothetical protein Dorea longicatena 6e-45 131/439 (29%) 12 MATE
LHK_00743 mdfA Probable multidrug translocase protein C. violaceum e-139 253/394 (64%) 12 MFS
LHK_01214   Probable multiple antibiotic resistance protein MarC C. violaceum 7e-58 118/208 (56%) -- MarC
LHK_01285 mdtA Probable membrane protein C. violaceum 3e-94 188/340 (55%) -- MFP
LHK_01286_01287 mdtB Drug efflux pump transmembrane protein C. violaceum 0 700/1018 (68%) 12 RND
LHK_01288 mdtC Drug efflux pump transmembrane protein C. violaceum 0 678/994 (68%) 10 RND
LHK_01289 tolC Putative outer membrane protein precursor Acinetobacter sp. 4e-79 189/433 (43%) -- OMP
LHK_01373 emrB Multidrug resistance protein C. violaceum 0 323/490 (65%) 14 MFS
LHK_01374 emrA Multidrug efflux membrane fusion protein Ralstonia eutropha e-101 194/370 (52%) -- MFP
LHK_01375 mdtP Outer membrane efflux protein Yersinia enterocolitica 1e-38 142/469 (30%) -- OMP
LHK_01376 emrR MarR family transcriptional regulator C. violaceum 4e-32 69/156 (44%) -- TR
LHK_01383   Probable multiple antibiotic resistance protein MarC C. violaceum 4e-80 149/232 (64%) -- MarC
LHK_01384 mdtJ Multidrug efflux system protein MdtJ Klebsiella pneumoniae 3e-20 52/119 (43%) 3 SMR
LHK_01385 mdtI Multidrug efflux system protein MdtI Salmonella enterica 6e-21 63/109 (57%) 4 SMR
LHK_01424   RND efflux system, outer membrane lipoprotein, NodT family Syntrophobacter fumaroxidans 7e-108 223/446 (50%) -- OMP
LHK_01425   Transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Pelobacter propionicus 0 553/1036 (53%) 12 RND
LHK_01426   Efflux transporter, RND family, MFP subunit S. fumaroxidans 7e-95 186/364 (51%) -- MFP
LHK_01870   Putative multidrug resistance protein R. eutropha 8e-47 153/483 (31%) 14 MFS
LHK_01934   Probable multiple antibiotic resistance protein MarC C. violaceum 3e-80 152/205 (74%) -- MarC
LHK_01967   ABC transporter, transmembrane region:ABC transporter related R. eutropha 0 550/732 (75%) 6 ABC
LHK_02051   Lipoprotein releasing system, ATP-binding protein Pseudomonas stutzeri 4e-58 134/227 (59%) -- ABC
LHK_02129 mexA Multidrug resistance protein Xanthomonas campestris 3e-104 223/375 (59%) -- MFP
LHK_02130 acrB AcrB/AcrD/AcrF family protein Cellvibrio japonicus 0 768/1034 (74%) 14 RND
LHK_02131 nodT RND efflux system, outer membrane lipoprotein, NodT Geobacter metallireducens 8e-142 266/466 (57%) -- OMP
LHK_02132   Transcriptional regulator, TetR/AcrR family Cellvibrio japonicus 2e-46 93/187 (49%) -- TR
LHK_02173   Probable MFS transporter C. violaceum 1e-82 195/370 (52%) 12 MFS
LHK_02235   Putative integral membrane efflux protein Yersinia pestis 0 379/505 (75%) 13 abgT family protein
LHK_02238   ABC transporter Azoarcus sp. e-157 281/371 (75%) 7 ABC
LHK_02239 yhiH ABC transporter related Thauera sp. 0 699/954 (73%) 6 ABC
LHK_02240   Conserved hypothetical protein, predicted secretion protein HlyD family Azoarcus sp. 6e-96 232/339 (68%) -- MFP
LHK_02241 oprM3 Outer membrane efflux protein B. avium 1e-100 241/453 (53%) -- OMP
LHK_02292   Probable multiple antibiotic resistance protein MarC C. violaceum 2e-60 116/218 (53%) -- MarC
LHK_02533   Multidrug efflux protein NorA C. violaceum e-122 230/447 (51%) 12 MATE
LHK_02539   EmrB/QacA family drug resistance transporter P. stutzeri 2e-147 277/481 (57%) 13 MFS
LHK_02783   Hypothetical protein multiple antibiotic resistance (MarC)-related protein C. violaceum 5e-74 139/200 (69%) -- MarC
LHK_02825 natC Periplasmic type I secretion system C. violaceum 4e-82 190/439 (43%) -- OMP
LHK_02826 acrB Probable transmembrane drug efflux protein C. violaceum 0 693/1019 (68%) 12 RND
LHK_02827 acrA Probable transport/efflux transmembrane protein C. violaceum 3e-83 174/351 (49%) -- MFP
LHK_02828 acrR TetR/AcrR family transcriptional regulator C. violaceum 6e-44 92/183 (50%) -- TR
LHK_02929 acrA Probable multidrug efflux membrane permease C. violaceum 1e-89 203/372 (54%) -- MFP
LHK_02930 acrD Acriflavin resistance protein D C. violaceum 0 717/1036 (69%) 12 RND
LHK_02931 oprM Outer membrane efflux protein C. violaceum e-136 252/467 (53%) -- OMP
LHK_02949 msbA Transport ATP-binding protein MsbA C. violaceum 0 344/554 (62%) 5 ABC
LHK_02975 bcr Probable MFS transporter C. violaceum e-147 269/388 (69%) 12 MFS
LHK_03132 emrB Probable multidrug resistance protein C. violaceum 0 303/492 (61%) 14 MFS
LHK_03133 emrA Multidrug resistance protein Burkholderia thailandensis 1e-108 202/377 (53%) -- MFP
LHK_03134 tolC Outer membrane efflux protein R. eutropha 6e-45 153/453 (33%) -- OMP
  1. aTMS, transmembrane segment domain
  2. bRND, resistance-nodulation-division family; MFS, major facilitator superfamily; ABC, ATP-binding cassette transporter superfamily; SMR, small multidrug resistance family; MATE, multidrug and toxic compound extrusion; MFP, membrane fusion protein; OMP, outer membrane (channel) protein; TR, transcription regulator; MarC, MarC-like protein.