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Figure 6 | Cell & Bioscience

Figure 6

From: Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production

Figure 6

IL-6 induction of TIMP-1 in primary hepatocytes is mediated via a STAT3-dependent mechanism. A, Hepatocytes (2 × 105 cells/per well) from wide-type or STAT3Hep-/- mice were cultured in 6-well plates and incubated with or without IL-6 (50 ng/ml) for 6 and 24 h, followed by real-time PCR analysis of TIMP-1 mRNA, B, or cultured for 24 and 48 h, followed by collection of the supernatants for measurement of TIMP-1 protein. Values are means ± SE from 4 independent experiments. *P < 0.05, and **P < 0.01 in comparison with the corresponding wild-type groups.

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