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Figure 5 | Cell & Bioscience

Figure 5

From: Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production

Figure 5

TIMP-1 is a survival factor for hepatocytes in vitro. Hepatocytes (2 × 105 cells/per well) were cultured in 6-well plates and incubated with or without cycloheximide (CHX) (100 μM) in the absence or presence of TIMP-1(100 ng/ml or 200 ng/ml). Hepatocyte death was determined by measurement of AST levels in the supernatants. *P < 0.05, **P < 0.01 vs. corresponding CHX group.

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