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Figure 4 | Cell & Bioscience

Figure 4

From: Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production

Figure 4

TIMP-1-/- mice are more susceptible to CCl4-induced chronic liver injury. Wild-type and TIMP-1-/- mice were treated with CCl4 for 4 weeks, and euthanized at various time points after the last injection. A, Serum ALT levels were assayed. B, The liver sections were stained with H&E and representative pictures are shown (original magnification × 100). C, D, TUNEL positive hepatocytes were counted (C) and representative pictures of TUNEL staining are shown (D). *P < 0.05.

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