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Figure 3 | Cell & Bioscience

Figure 3

From: Tissue inhibitor of metalloproteinase 1 (TIMP-1) deficiency exacerbates carbon tetrachloride-induced liver injury and fibrosis in mice: involvement of hepatocyte STAT3 in TIMP-1 production

Figure 3

TIMP-1-/- mice have greater liver fibrosis than wild-type mice post 4-week-CCl4 treatment. Mice were treated with CCl4 for 4 weeks and euthanized 24 hours following the last injection. A, B, Liver tissues were collected for Sirius red staining (A) and immunohistochemical staining with α-SMA antibodies (B). The surface areas stained with Sirius red or α-SMA were quantified and shown in the right panel. C, Western blot analyses of α-SMA from liver tissue protein extracts. The values represent values ± SEM (n = 5-8). *P < 0.05.

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