Systematic analysis of secreted proteins reveals synergism between IL6 and other proteins in soft agar growth of MCF10A cells

Table 1 List of DNA inserts from screen colonies

total inserts	% of all inserts	protein	Protein family	Description	Role in Breast cancer
68	6.9%	WFDC13	WFDC	WAP Four-Disulfide Core Domain 13	no
36	3.6%	PON1	PON	Paraoxonase 1	no
31	3.1%	Wnt3	Wnt	Wingless-type MMTV Integration Site Family, Member 3	[7]
18	1.8%	FGFBP2	FGFBP	Fibroblast Growth Factor Binding Protein 2	no
15	1.5%	IL6	Interleukin	Interleukin 6 (Interferon, Beta 2)	[10]
15	1.5%	FGF14	FGF	Fibroblast Growth Factor 14	no
14	1.4%	SAA1	SAA	Serum Amyloid A1	[24]
14	1.4%	PTHLH	PTHLH	Parathyroid Hormone-Like Hormone	[23]
13	1.3%	FGF10	FGF	Fibroblast Growth Factor 10	[6]
12	1.2%	LYNX1	Ly-6	Ly6/Neurotoxin 1	No
12	1.2%	IL21	Interleukin	Interleukin 21	Refs in [38]
11	1.1%	IL22	Interleukin	Interleukin 22	[16]
10	1.0%	WFDC14	WFDC	Peptidase Inhibitor 3, Skin-Derived (SKALP)	no
10	1.0%	SUMF1	SUMF	Sulfatase Modifying Factor 1	no
10	1.0%	FGF1	FGF	Fibroblast Growth Factor 1 (acidic)	[22]

The most recurrent DNA inserts recovered from screen colonies are listed, with indication of the protein family they belong to, and publications linking the proteins to breast cancer development.