From: Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment
Macrophage-derived factors/receptors | Fibroblast-derived factors/receptors | Function | References |
---|---|---|---|
CSF1R | CSF1 | Induce M2 polarization in monocytes | [88] |
CCR2 | CCL2 | Promote myeloid cell infiltration | |
unclear now | CXCL14 | Increase macrophage infiltration | [92] |
CXCR4 | CXCL12 | Promote macrophage recruitment and M2 polarization; promote LAM differentiation | |
CXCR6 | CXCL16 | Promote macrophage recruitment | [95] |
IL-6R | IL-6 | Promote preinvasive TAM differentiation | Â |
ST2 | IL-33 | Promote macrophage recruitment and polarization; promote MMP9 secretion of TAMs | [99] |
C3aR | C3a | Promote monocyte differentiation to TAMs | |
CXCL3 | CXCR2 | Induce CAF-to-myofibroblasts transition | [113] |
OSM | OSMR | Induce inflammatory fibroblasts | [114] |
IL-1β | IL-R1 | Induce conversion of NFs to CAFs; Induce CAF production of IL-8 and GROα | |
CXCR2 | IL-8 | Induce immunosuppressive TAMs to suppress NK cells | [102] |
CXCR4 | SDF-1 | Induce immunosuppressive TAMs to suppress T cells | [107] |
unclear now | HIF2 | Promote macrophage M2 polarization; Regulate TAM expression of immune checkpoint | [109] |
PTGIR | PGI2 | Induce mixed-polarized TAM phenotype with reduced phagocytic capability | [125] |
Granulin | unclear now | Activate myofibroblasts to induce ECM remodelling | [119] |
TGF-β1 | TGFβR2 | Activate CAFs to induce ECM remodelling | [120] |