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  1. Research

    The role of GLI1 for 5-Fu resistance in colorectal cancer

    Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cance...

    Lining Zhang, Ruolan Song, Dongsheng Gu, Xiaoli Zhang, Beiqin Yu, Bingya Liu and Jingwu Xie

    Cell & Bioscience 2017 7:17

    Published on: 13 April 2017

  2. Research

    Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression

    Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...

    Qiushuang Xiong, Shaoshuai Wu, Jingwen Wang, Xianhuang Zeng, Jianwen Chen, Mingcong Wei, Haotong Guan, Chengpeng Fan, Lang Chen, Deyin Guo and Guihong Sun

    Cell & Bioscience 2017 7:16

    Published on: 12 April 2017

  3. Research

    Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

    Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during m...

    Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu and Xingzhi Xu

    Cell & Bioscience 2017 7:15

    Published on: 23 March 2017

  4. Review

    microRNA and thyroid hormone signaling in cardiac and skeletal muscle

    Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...

    Duo Zhang, Yan Li, Shengnan Liu, Yu-cheng Wang, Feifan Guo, Qiwei Zhai, Jingjing Jiang and Hao Ying

    Cell & Bioscience 2017 7:14

    Published on: 21 March 2017

  5. Review

    Mechanism of transcription-coupled DNA modification recognition

    As a key enzyme for gene expression, RNA polymerase II (pol II) reads along the DNA template and catalyzes accurate mRNA synthesis during transcription. On the other hand, genomic DNA is under constant attack ...

    Ji Hyun Shin, Liang Xu and Dong Wang

    Cell & Bioscience 2017 7:9

    Published on: 22 February 2017

  6. Review

    Maintenance of genome stability by Fanconi anemia proteins

    Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancer...

    Anna Palovcak, Wenjun Liu, Fenghua Yuan and Yanbin Zhang

    Cell & Bioscience 2017 7:8

    Published on: 22 February 2017

  7. Research highlight

    Yeast help identify cytopathic factors of Zika virus

    Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these ...

    Michael Bukrinsky

    Cell & Bioscience 2017 7:12

    Published on: 20 February 2017

  8. Research

    Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells

    Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for i...

    Bingfei Zhou, Min Chu, Shanshan Xu, Xiong Chen, Yongjuan Liu, Zhihao Wang, Fengfeng Zhang, Song Han, Jun Yin, Biwen Peng, Xiaohua He and Wanhong Liu

    Cell & Bioscience 2017 7:7

    Published on: 14 January 2017

  9. Review

    Microhomology-mediated end joining: new players join the team

    DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomi...

    Hailong Wang and Xingzhi Xu

    Cell & Bioscience 2017 7:6

    Published on: 13 January 2017

  10. Research

    A fission yeast cell-based system for multidrug resistant HIV-1 proteases

    HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patie...

    Zsigmond Benko, Dong Liang, Ge Li, Robert T. Elder, Anindya Sarkar, Jun Takayama, Arun K. Ghosh and Richard Y. Zhao

    Cell & Bioscience 2017 7:5

    Published on: 11 January 2017

  11. Letter to the Editor

    Characterization of tubular liquid crystal structure in embryonic stem cell derived embryoid bodies

    Massive liquid crystal droplets have been found during embryonic development in more than twenty different tissues and organs, including the liver, brain and kidney. Liquid crystal deposits have also been iden...

    MengMeng Xu, Odell D. Jones, Liyang Wang, Xin Zhou, Harry G. Davis, Joseph L. Bryant, Jianjie Ma, Willian B. Isaacs and Xuehong Xu

    Cell & Bioscience 2017 7:3

    Published on: 3 January 2017

  12. Review

    Targeted genome engineering in Caenorhabditis elegans

    The generation of mutants and transgenes are indispensible for biomedical research. In the nematode Caenorhabditis elegans, a series of methods have been developed to introduce genome modifications, including ran...

    Xiangyang Chen, Xuezhu Feng and Shouhong Guang

    Cell & Bioscience 2016 6:60

    Published on: 8 December 2016

  13. Review

    Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration

    One of the two common hallmark lesions of Alzheimer’s disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of o...

    Onder Albayram, Megan K. Herbert, Asami Kondo, Cheng-Yu Tsai, Sean Baxley, Xiaolan Lian, Madison Hansen, Xiao Zhen Zhou and Kun Ping Lu

    Cell & Bioscience 2016 6:59

    Published on: 5 December 2016

  14. Research

    Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6

    Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear.

    Yu Han, Hongdang Xu, Jiangtao Cheng, Yanwei Zhang, Chuanyu Gao, Taibing Fan, Bangtian Peng, Bin Li, Lin Liu and Zhaoyun Cheng

    Cell & Bioscience 2016 6:58

    Published on: 22 November 2016

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