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  1. Review

    The roles of microRNA families in hepatic fibrosis

    When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists...

    Xue-Ping Jiang, Wen-Bing Ai, Lin-Yan Wan, Yan-Qiong Zhang and Jiang-Feng Wu

    Cell & Bioscience 2017 7:34

    Published on: 4 July 2017

  2. Research

    Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

    Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Kv1....

    Jie Huang, Song Han, Qi Sun, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Jun Yin and Xiaohua He

    Cell & Bioscience 2017 7:31

    Published on: 7 June 2017

  3. Research highlight

    iPSCs are safe!

    Induced pluripotent stem cells (iPSCs) hold great promises in cell therapy. However, the potential safety issues have dampened the enthusiasm of their clinical development. One of the biggest concerns came fro...

    Hualong Yan, Yun-Bo Shi and Jing Huang

    Cell & Bioscience 2017 7:30

    Published on: 30 May 2017

  4. Review

    APOBEC3B, a molecular driver of mutagenesis in human cancers

    Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for ge...

    Jun Zou, Chen Wang, Xiangyi Ma, Edward Wang and Guang Peng

    Cell & Bioscience 2017 7:29

    Published on: 30 May 2017

  5. Research

    Epigenetic regulation of Runx2 transcription and osteoblast differentiation by nicotinamide phosphoribosyltransferase

    Bone degenerative disorders like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Although there are studies suggesting that metabolic chan...

    Min Ling, Peixin Huang, Shamima Islam, Daniel P. Heruth, Xuanan Li, Li Qin Zhang, Ding-You Li, Zhaohui Hu and Shui Qing Ye

    Cell & Bioscience 2017 7:27

    Published on: 23 May 2017

  6. Research

    Histone demethylases UTX and JMJD3 are required for NKT cell development in mice

    Natural killer (NK)T cells and conventional T cells share phenotypic characteristic however they differ in transcription factor requirements and functional properties. The role of histone modifying enzymes in ...

    Daniel Northrup, Ryoji Yagi, Kairong Cui, William R. Proctor, Chaochen Wang, Katarzyna Placek, Lance R. Pohl, Rongfu Wang, Kai Ge, Jinfang Zhu and Keji Zhao

    Cell & Bioscience 2017 7:25

    Published on: 17 May 2017

  7. Research

    Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb deletion in the OCA2 gene revealed a co-segregation of the controversial variant, p.R305W

    Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene. Diagnostic sequencing of...

    Jackson Gao, Leera D’Souza, Keith Wetherby, Christian Antolik, Melissa Reeves, David R. Adams, Santa Tumminia and Xinjing Wang

    Cell & Bioscience 2017 7:22

    Published on: 26 April 2017

  8. Review

    Plant genome editing with TALEN and CRISPR

    Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks a...

    Aimee Malzahn, Levi Lowder and Yiping Qi

    Cell & Bioscience 2017 7:21

    Published on: 24 April 2017

  9. Research

    The role of GLI1 for 5-Fu resistance in colorectal cancer

    Colorectal cancer is a leading cause of cancer-related mortality worldwide, with Fluorouracil (5-FU)-based chemotherapy as the major treatment for advanced disease. Many patients with advanced colorectal cance...

    Lining Zhang, Ruolan Song, Dongsheng Gu, Xiaoli Zhang, Beiqin Yu, Bingya Liu and Jingwu Xie

    Cell & Bioscience 2017 7:17

    Published on: 13 April 2017

  10. Research

    Hepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression

    Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...

    Qiushuang Xiong, Shaoshuai Wu, Jingwen Wang, Xianhuang Zeng, Jianwen Chen, Mingcong Wei, Haotong Guan, Chengpeng Fan, Lang Chen, Deyin Guo and Guihong Sun

    Cell & Bioscience 2017 7:16

    Published on: 12 April 2017

  11. Research

    Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

    Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during m...

    Bin Peng, Ruifeng Shi, Weiwei Jiang, Yue-He Ding, Meng-Qiu Dong, Wei-Guo Zhu and Xingzhi Xu

    Cell & Bioscience 2017 7:15

    Published on: 23 March 2017

  12. Review

    microRNA and thyroid hormone signaling in cardiac and skeletal muscle

    Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant ...

    Duo Zhang, Yan Li, Shengnan Liu, Yu-cheng Wang, Feifan Guo, Qiwei Zhai, Jingjing Jiang and Hao Ying

    Cell & Bioscience 2017 7:14

    Published on: 21 March 2017

  13. Review

    Mechanism of transcription-coupled DNA modification recognition

    As a key enzyme for gene expression, RNA polymerase II (pol II) reads along the DNA template and catalyzes accurate mRNA synthesis during transcription. On the other hand, genomic DNA is under constant attack ...

    Ji Hyun Shin, Liang Xu and Dong Wang

    Cell & Bioscience 2017 7:9

    Published on: 22 February 2017

  14. Review

    Maintenance of genome stability by Fanconi anemia proteins

    Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancer...

    Anna Palovcak, Wenjun Liu, Fenghua Yuan and Yanbin Zhang

    Cell & Bioscience 2017 7:8

    Published on: 22 February 2017

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