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  1. Research highlight

    Yeast help identify cytopathic factors of Zika virus

    Accumulating evidence implicates Zika virus (ZIKV) in pathogenesis of microcephaly in newborns and Guillain-Barré syndrome in adults. However, it remains unclear which viral proteins are responsible for these ...

    Michael Bukrinsky

    Cell & Bioscience 2017 7:12

    Published on: 20 February 2017

  2. Research

    Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells

    Human enterovirus 71 (EV71) causes severe hand, foot and mouse disease, accompanied by neurological complications. During the interaction between EV71 and the host, the virus subverts host cell machinery for i...

    Bingfei Zhou, Min Chu, Shanshan Xu, Xiong Chen, Yongjuan Liu, Zhihao Wang, Fengfeng Zhang, Song Han, Jun Yin, Biwen Peng, Xiaohua He and Wanhong Liu

    Cell & Bioscience 2017 7:7

    Published on: 14 January 2017

  3. Review

    Microhomology-mediated end joining: new players join the team

    DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomi...

    Hailong Wang and Xingzhi Xu

    Cell & Bioscience 2017 7:6

    Published on: 13 January 2017

  4. Research

    A fission yeast cell-based system for multidrug resistant HIV-1 proteases

    HIV-1 protease (PR) is an essential enzyme for viral production. Thus, PR inhibitors (PIs) are the most effective class of anti-HIV drugs. However, the main challenge to the successful use of PI drugs in patie...

    Zsigmond Benko, Dong Liang, Ge Li, Robert T. Elder, Anindya Sarkar, Jun Takayama, Arun K. Ghosh and Richard Y. Zhao

    Cell & Bioscience 2017 7:5

    Published on: 11 January 2017

  5. Letter to the Editor

    Characterization of tubular liquid crystal structure in embryonic stem cell derived embryoid bodies

    Massive liquid crystal droplets have been found during embryonic development in more than twenty different tissues and organs, including the liver, brain and kidney. Liquid crystal deposits have also been iden...

    MengMeng Xu, Odell D. Jones, Liyang Wang, Xin Zhou, Harry G. Davis, Joseph L. Bryant, Jianjie Ma, Willian B. Isaacs and Xuehong Xu

    Cell & Bioscience 2017 7:3

    Published on: 3 January 2017

  6. Review

    Targeted genome engineering in Caenorhabditis elegans

    The generation of mutants and transgenes are indispensible for biomedical research. In the nematode Caenorhabditis elegans, a series of methods have been developed to introduce genome modifications, including ran...

    Xiangyang Chen, Xuezhu Feng and Shouhong Guang

    Cell & Bioscience 2016 6:60

    Published on: 8 December 2016

  7. Review

    Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration

    One of the two common hallmark lesions of Alzheimer’s disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of o...

    Onder Albayram, Megan K. Herbert, Asami Kondo, Cheng-Yu Tsai, Sean Baxley, Xiaolan Lian, Madison Hansen, Xiao Zhen Zhou and Kun Ping Lu

    Cell & Bioscience 2016 6:59

    Published on: 5 December 2016

  8. Research

    Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6

    Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear.

    Yu Han, Hongdang Xu, Jiangtao Cheng, Yanwei Zhang, Chuanyu Gao, Taibing Fan, Bangtian Peng, Bin Li, Lin Liu and Zhaoyun Cheng

    Cell & Bioscience 2016 6:58

    Published on: 22 November 2016

  9. Review

    MAP4K4: an emerging therapeutic target in cancer

    The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later fo...

    Xuan Gao, Chenxi Gao, Guoxiang Liu and Jing Hu

    Cell & Bioscience 2016 6:56

    Published on: 28 October 2016

  10. Research

    Roxarsone induces angiogenesis via PI3K/Akt signaling

    3-Nitro-4-hydroxy phenyl arsenic acid, roxarsone, is widely used as an organic arsenic feed additive for livestock and poultry, which may increase the level of arsenic in the environment and the risk of exposu...

    Yujing Wang, Donglai Yin, Chao Xu, Kai Wang, Lingmin Zheng and Yumei Zhang

    Cell & Bioscience 2016 6:54

    Published on: 28 September 2016

  11. Review

    A new paradigm of DNA synthesis: three-metal-ion catalysis

    Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...

    Wei Yang, Peter J. Weng and Yang Gao

    Cell & Bioscience 2016 6:51

    Published on: 6 September 2016

    The Erratum to this article has been published in Cell & Bioscience 2017 7:32

  12. Research

    Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway

    Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...

    Hye-Ryun Kim, Jong-Hee Lee, Hye-Ryeon Heo, Se-Ran Yang, Kwon-Soo Ha, Won Sun Park, Eun-Taek Han, Haengseok Song and Seok-Ho Hong

    Cell & Bioscience 2016 6:50

    Published on: 30 August 2016

  13. Letter to the Editor

    Analysis of Axin2 expression and function in murine models for pancreatic cancer

    The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...

    Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke and Brigitte Vollmar

    Cell & Bioscience 2016 6:49

    Published on: 22 August 2016

  14. Research

    Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

    General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...

    Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li and Chundong Yu

    Cell & Bioscience 2016 6:47

    Published on: 2 August 2016

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