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  1. Review

    Targeted genome engineering in Caenorhabditis elegans

    The generation of mutants and transgenes are indispensible for biomedical research. In the nematode Caenorhabditis elegans, a series of methods have been developed to introduce genome modifications, including ran...

    Xiangyang Chen, Xuezhu Feng and Shouhong Guang

    Cell & Bioscience 2016 6:60

    Published on: 8 December 2016

  2. Review

    Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration

    One of the two common hallmark lesions of Alzheimer’s disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of o...

    Onder Albayram, Megan K. Herbert, Asami Kondo, Cheng-Yu Tsai, Sean Baxley, Xiaolan Lian, Madison Hansen, Xiao Zhen Zhou and Kun Ping Lu

    Cell & Bioscience 2016 6:59

    Published on: 5 December 2016

  3. Research

    Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6

    Regulating cardiac differentiation to maintain normal heart development and function is very important. At present, biological functions of H19 in cardiac differentiation is not completely clear.

    Yu Han, Hongdang Xu, Jiangtao Cheng, Yanwei Zhang, Chuanyu Gao, Taibing Fan, Bangtian Peng, Bin Li, Lin Liu and Zhaoyun Cheng

    Cell & Bioscience 2016 6:58

    Published on: 22 November 2016

  4. Review

    MAP4K4: an emerging therapeutic target in cancer

    The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later fo...

    Xuan Gao, Chenxi Gao, Guoxiang Liu and Jing Hu

    Cell & Bioscience 2016 6:56

    Published on: 28 October 2016

  5. Research

    Roxarsone induces angiogenesis via PI3K/Akt signaling

    3-Nitro-4-hydroxy phenyl arsenic acid, roxarsone, is widely used as an organic arsenic feed additive for livestock and poultry, which may increase the level of arsenic in the environment and the risk of exposu...

    Yujing Wang, Donglai Yin, Chao Xu, Kai Wang, Lingmin Zheng and Yumei Zhang

    Cell & Bioscience 2016 6:54

    Published on: 28 September 2016

  6. Review

    A new paradigm of DNA synthesis: three-metal-ion catalysis

    Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...

    Wei Yang, Peter J. Weng and Yang Gao

    Cell & Bioscience 2016 6:51

    Published on: 6 September 2016

  7. Research

    Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway

    Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...

    Hye-Ryun Kim, Jong-Hee Lee, Hye-Ryeon Heo, Se-Ran Yang, Kwon-Soo Ha, Won Sun Park, Eun-Taek Han, Haengseok Song and Seok-Ho Hong

    Cell & Bioscience 2016 6:50

    Published on: 30 August 2016

  8. Letter to the Editor

    Analysis of Axin2 expression and function in murine models for pancreatic cancer

    The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...

    Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke and Brigitte Vollmar

    Cell & Bioscience 2016 6:49

    Published on: 22 August 2016

  9. Research

    Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

    General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...

    Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li and Chundong Yu

    Cell & Bioscience 2016 6:47

    Published on: 2 August 2016

  10. Research

    EphA5 and EphA6: regulation of neuronal and spine morphology

    The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and ...

    Gitanjali Das, Qili Yu, Ryan Hui, Kenneth Reuhl, Nicholas W. Gale and Renping Zhou

    Cell & Bioscience 2016 6:48

    Published on: 2 August 2016

  11. Research

    Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts

    Rheumatoid arthritis (RA) is characterized by excessive synovial inflammation. Cyclooxygenase-2 (COX-2) is an enzyme that catalyzes the conversion of arachidonic acid (AA) into prostaglandins. Epithelium-speci...

    Chan-Mi Lee, Sahil Gupta, Jiafeng Wang, Elizabeth M. Johnson, Leslie J. Crofford, John C. Marshall, Mohit Kapoor and Jim Hu

    Cell & Bioscience 2016 6:43

    Published on: 16 June 2016

  12. Research

    Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

    The complications of clinical metastatic disease are responsible for the majority of breast cancer related deaths, and fewer therapies substantially prolong survival. Nitidine chloride (NC), a natural polyphen...

    Mingjuan Sun, Ning Zhang, Xiaolong Wang, Yaming Li, Wenwen Qi, Hanwen Zhang, Zengjun Li and Qifeng Yang

    Cell & Bioscience 2016 6:44

    Published on: 16 June 2016

  13. Research

    Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice

    Concerted hormone secretion is essential for glucose homeostasis and growth. The oocyte testis gene 1 (Otg1) has limited information in mammals before. Human OTG1 has been identified as an antigen associated with...

    Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han and Xiaohui Wu

    Cell & Bioscience 2016 6:41

    Published on: 10 June 2016

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