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  1. Review

    A new paradigm of DNA synthesis: three-metal-ion catalysis

    Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...

    Wei Yang, Peter J. Weng and Yang Gao

    Cell & Bioscience 2016 6:51

    Published on: 6 September 2016

  2. Research

    Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway

    Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...

    Hye-Ryun Kim, Jong-Hee Lee, Hye-Ryeon Heo, Se-Ran Yang, Kwon-Soo Ha, Won Sun Park, Eun-Taek Han, Haengseok Song and Seok-Ho Hong

    Cell & Bioscience 2016 6:50

    Published on: 30 August 2016

  3. Letter to the Editor

    Analysis of Axin2 expression and function in murine models for pancreatic cancer

    The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...

    Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke and Brigitte Vollmar

    Cell & Bioscience 2016 6:49

    Published on: 22 August 2016

  4. Research

    Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

    General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...

    Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li and Chundong Yu

    Cell & Bioscience 2016 6:47

    Published on: 2 August 2016

  5. Research

    EphA5 and EphA6: regulation of neuronal and spine morphology

    The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and ...

    Gitanjali Das, Qili Yu, Ryan Hui, Kenneth Reuhl, Nicholas W. Gale and Renping Zhou

    Cell & Bioscience 2016 6:48

    Published on: 2 August 2016

  6. Research

    Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts

    Rheumatoid arthritis (RA) is characterized by excessive synovial inflammation. Cyclooxygenase-2 (COX-2) is an enzyme that catalyzes the conversion of arachidonic acid (AA) into prostaglandins. Epithelium-speci...

    Chan-Mi Lee, Sahil Gupta, Jiafeng Wang, Elizabeth M. Johnson, Leslie J. Crofford, John C. Marshall, Mohit Kapoor and Jim Hu

    Cell & Bioscience 2016 6:43

    Published on: 16 June 2016

  7. Research

    Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

    The complications of clinical metastatic disease are responsible for the majority of breast cancer related deaths, and fewer therapies substantially prolong survival. Nitidine chloride (NC), a natural polyphen...

    Mingjuan Sun, Ning Zhang, Xiaolong Wang, Yaming Li, Wenwen Qi, Hanwen Zhang, Zengjun Li and Qifeng Yang

    Cell & Bioscience 2016 6:44

    Published on: 16 June 2016

  8. Research

    Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice

    Concerted hormone secretion is essential for glucose homeostasis and growth. The oocyte testis gene 1 (Otg1) has limited information in mammals before. Human OTG1 has been identified as an antigen associated with...

    Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han and Xiaohui Wu

    Cell & Bioscience 2016 6:41

    Published on: 10 June 2016

  9. Research

    Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells

    The single-stranded RNA Flavivirus, Zika virus (ZIKV), has recently re-emerged and spread rapidly across the western hemisphere’s equatorial countries, primarily through Aedes mosquito transmission. While symptom...

    Alyssa J. Rolfe, Dale B. Bosco, Jingying Wang, Richard S. Nowakowski, Jianqing Fan and Yi Ren

    Cell & Bioscience 2016 6:42

    Published on: 10 June 2016

  10. Research

    Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy

    Leiomodin proteins, Lmod1, Lmod2 and Lmod3, are key regulators of the thin filament length in muscles. While Lmod1 is specifically expressed in smooth muscles, both Lmod2 and Lmod3 are expressed in striated muscl...

    Shuang Li, Kaiqi Mo, Hong Tian, Chen Chu, Shuna Sun, Lei Tian, Sheng Ding, Tong-ruei Li, Xiaohui Wu, Fang Liu, Zhen Zhang, Tian Xu and Ling V. Sun

    Cell & Bioscience 2016 6:38

    Published on: 4 June 2016

  11. Research

    Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathway

    Diabetes mellitus has multiple complications including neuropathy and increases cardiovascular events. Paeoniflorin (PF), a monoterpene glycoside, plays an essential role in neuroprotection and ischemic heart ...

    Fei Han, Dongchen Zhou, Xiang Yin, Zewei Sun, Jie Han, Lifang Ye, Wengting Zhao, Yuanyuan Zhang, Zhen Wang and Liangrong Zheng

    Cell & Bioscience 2016 6:37

    Published on: 1 June 2016

  12. Research

    Exogenous H2S modulates mitochondrial fusion–fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state

    Vascular smooth muscle cell (VSMC) proliferation in response to hyperglycemia is an important process in the development of arterial vessel hyperplasia. The shape change of mitochondria is dynamic and closely ...

    Aili Sun, Yan Wang, Jiaqi Liu, Xiangjing Yu, Yu Sun, Fan Yang, Shiyun Dong, Jichao Wu, Yajun Zhao, Changqing Xu, Fanghao Lu and Weihua Zhang

    Cell & Bioscience 2016 6:36

    Published on: 31 May 2016

  13. Research

    Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

    Myeloproliferative neoplasms (MPN) are a group of blood cancers that boost normal blood cell production in the bone marrow. Abnormal mutations in stem cells were found accompanying with the occurrence of MPN. ...

    Chunjie Yu, Qiong Yang, Yuhong Chen, Demin Wang, Ross Levine, John Crispino, Qiang Wen and Zan Huang

    Cell & Bioscience 2016 6:34

    Published on: 23 May 2016

  14. Research

    Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

    Excessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on ...

    Jiaqi Liu, Jichao Wu, Aili Sun, Yu Sun, Xiangjing Yu, Ning Liu, Shiyun Dong, Fan Yang, Linxue Zhang, Xin Zhong, Changqing Xu, Fanghao Lu and Weihua Zhang

    Cell & Bioscience 2016 6:33

    Published on: 23 May 2016

  15. Review

    Circulating tumor DNA in hepatocellular carcinoma: trends and challenges

    Molecular characterization of individual patients’ tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated ...

    Jia-Cheng Tang, Yi-Li Feng, Tao Guo, An-Yong Xie and Xiu-Jun Cai

    Cell & Bioscience 2016 6:32

    Published on: 11 May 2016

  16. Research

    SP1 and UTE1 Decoy ODNs inhibit activation and proliferation of hepatic stellate cells by targeting tissue inhibitors of metalloproteinase 1

    The excessive accumulation of extracellular matrix of hepatic fibrosis is positively correlated with tissue inhibitors of metalloproteinase 1 (TIMP1). Here we aimed to investigate whether TIMP1 may be down-reg...

    Dong Jia, Yi-Ran Ni, Yan-Qiong Zhang, Chun Rao, Jun Hou, He-Qing Tang, Chang-Bai Liu and Jiang-Feng Wu

    Cell & Bioscience 2016 6:31

    Published on: 10 May 2016

  17. Research

    IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia

    Lymphopenia promotes naïve T-cell homeostatic proliferation and adoptive effector T-cell survival and memory formation. IL-7 plays a critical role in homeostatic proliferation, survival and memory formation of...

    Aizhang Xu, Kalpana Kalyanasundaram Bhanumathy, Jie Wu, Zhenmin Ye, Andrew Freywald, Scot C. Leary, Rongxiu Li and Jim Xiang

    Cell & Bioscience 2016 6:30

    Published on: 6 May 2016

  18. Letter to the Editor

    Studies of genetic variability of the hepatocyte nuclear factor-1α gene in an Indian maturity-onset diabetes of the young family

    Maturity-onset diabetes of the young (MODY), one of the specific types of diabetes mellitus, is a monogenetic disorder characterized by an autosomal dominant (AD) inheritance and β-cell dysfunction. To study a...

    Jing Yang, Feng Jiang, Hui Guo, Thadimacca Soniya, Chun-xia Yan, Zhu-fang Tian and Bing-yin Shi

    Cell & Bioscience 2016 6:29

    Published on: 4 May 2016

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