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  1. Review

    MAP4K4: an emerging therapeutic target in cancer

    The serine/threonine kinase MAP4K4 is a member of the Ste20p (sterile 20 protein) family. MAP4K4 was initially discovered in 1995 as a key kinase in the mating pathway in Saccharomyces cerevisiae and was later fo...

    Xuan Gao, Chenxi Gao, Guoxiang Liu and Jing Hu

    Cell & Bioscience 2016 6:56

    Published on: 28 October 2016

  2. Research

    Roxarsone induces angiogenesis via PI3K/Akt signaling

    3-Nitro-4-hydroxy phenyl arsenic acid, roxarsone, is widely used as an organic arsenic feed additive for livestock and poultry, which may increase the level of arsenic in the environment and the risk of exposu...

    Yujing Wang, Donglai Yin, Chao Xu, Kai Wang, Lingmin Zheng and Yumei Zhang

    Cell & Bioscience 2016 6:54

    Published on: 28 September 2016

  3. Review

    A new paradigm of DNA synthesis: three-metal-ion catalysis

    Enzyme catalysis has been studied for over a century. How it actually occurs has not been visualized until recently. By combining in crystallo reaction and X-ray diffraction analysis of reaction intermediates,...

    Wei Yang, Peter J. Weng and Yang Gao

    Cell & Bioscience 2016 6:51

    Published on: 6 September 2016

  4. Research

    Improved hematopoietic differentiation of human pluripotent stem cells via estrogen receptor signaling pathway

    Aside from its importance in reproduction, estrogen (E2) is known to regulate the proliferation and differentiation of hematopoietic stem cells in rodents. However, the regulatory role of E2 in human hematopoi...

    Hye-Ryun Kim, Jong-Hee Lee, Hye-Ryeon Heo, Se-Ran Yang, Kwon-Soo Ha, Won Sun Park, Eun-Taek Han, Haengseok Song and Seok-Ho Hong

    Cell & Bioscience 2016 6:50

    Published on: 30 August 2016

  5. Letter to the Editor

    Analysis of Axin2 expression and function in murine models for pancreatic cancer

    The involvement of Wnt in carcinogenesis and progression of pancreatic cancer is currently intensely discussed. We evaluated activation of the Wnt signaling pathway by using a Wnt reporter mouse strain express...

    Dietmar Zechner, Tim Kroemer, Ann-Christin Albert, Maria Schönrogge, Tobias Radecke and Brigitte Vollmar

    Cell & Bioscience 2016 6:49

    Published on: 22 August 2016

  6. Research

    Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

    General control non-depressible 5 (GCN5) is a crucial catalytic component of a transcriptional regulatory complex that plays important roles in cellular functions from cell cycle regulation to DNA damage repai...

    Sidra Majaz, Zhangwei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Pingli Mo, Wengang Li and Chundong Yu

    Cell & Bioscience 2016 6:47

    Published on: 2 August 2016

  7. Research

    EphA5 and EphA6: regulation of neuronal and spine morphology

    The Eph family of receptor tyrosine kinases plays important roles in neural development. Previous studies have implicated Eph receptors and their ligands, the ephrins, in neuronal migration, axon bundling and ...

    Gitanjali Das, Qili Yu, Ryan Hui, Kenneth Reuhl, Nicholas W. Gale and Renping Zhou

    Cell & Bioscience 2016 6:48

    Published on: 2 August 2016

  8. Research

    Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts

    Rheumatoid arthritis (RA) is characterized by excessive synovial inflammation. Cyclooxygenase-2 (COX-2) is an enzyme that catalyzes the conversion of arachidonic acid (AA) into prostaglandins. Epithelium-speci...

    Chan-Mi Lee, Sahil Gupta, Jiafeng Wang, Elizabeth M. Johnson, Leslie J. Crofford, John C. Marshall, Mohit Kapoor and Jim Hu

    Cell & Bioscience 2016 6:43

    Published on: 16 June 2016

  9. Research

    Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

    The complications of clinical metastatic disease are responsible for the majority of breast cancer related deaths, and fewer therapies substantially prolong survival. Nitidine chloride (NC), a natural polyphen...

    Mingjuan Sun, Ning Zhang, Xiaolong Wang, Yaming Li, Wenwen Qi, Hanwen Zhang, Zengjun Li and Qifeng Yang

    Cell & Bioscience 2016 6:44

    Published on: 16 June 2016

  10. Research

    Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice

    Concerted hormone secretion is essential for glucose homeostasis and growth. The oocyte testis gene 1 (Otg1) has limited information in mammals before. Human OTG1 has been identified as an antigen associated with...

    Guangxue Wang, Rongbo Li, Ying Yang, Liang Cai, Sheng Ding, Tian Xu, Min Han and Xiaohui Wu

    Cell & Bioscience 2016 6:41

    Published on: 10 June 2016

  11. Research

    Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cells

    The single-stranded RNA Flavivirus, Zika virus (ZIKV), has recently re-emerged and spread rapidly across the western hemisphere’s equatorial countries, primarily through Aedes mosquito transmission. While symptom...

    Alyssa J. Rolfe, Dale B. Bosco, Jingying Wang, Richard S. Nowakowski, Jianqing Fan and Yi Ren

    Cell & Bioscience 2016 6:42

    Published on: 10 June 2016

  12. Research

    Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy

    Leiomodin proteins, Lmod1, Lmod2 and Lmod3, are key regulators of the thin filament length in muscles. While Lmod1 is specifically expressed in smooth muscles, both Lmod2 and Lmod3 are expressed in striated muscl...

    Shuang Li, Kaiqi Mo, Hong Tian, Chen Chu, Shuna Sun, Lei Tian, Sheng Ding, Tong-ruei Li, Xiaohui Wu, Fang Liu, Zhen Zhang, Tian Xu and Ling V. Sun

    Cell & Bioscience 2016 6:38

    Published on: 4 June 2016

  13. Research

    Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathway

    Diabetes mellitus has multiple complications including neuropathy and increases cardiovascular events. Paeoniflorin (PF), a monoterpene glycoside, plays an essential role in neuroprotection and ischemic heart ...

    Fei Han, Dongchen Zhou, Xiang Yin, Zewei Sun, Jie Han, Lifang Ye, Wengting Zhao, Yuanyuan Zhang, Zhen Wang and Liangrong Zheng

    Cell & Bioscience 2016 6:37

    Published on: 1 June 2016

  14. Research

    Exogenous H2S modulates mitochondrial fusion–fission to inhibit vascular smooth muscle cell proliferation in a hyperglycemic state

    Vascular smooth muscle cell (VSMC) proliferation in response to hyperglycemia is an important process in the development of arterial vessel hyperplasia. The shape change of mitochondria is dynamic and closely ...

    Aili Sun, Yan Wang, Jiaqi Liu, Xiangjing Yu, Yu Sun, Fan Yang, Shiyun Dong, Jichao Wu, Yajun Zhao, Changqing Xu, Fanghao Lu and Weihua Zhang

    Cell & Bioscience 2016 6:36

    Published on: 31 May 2016

  15. Research

    Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

    Myeloproliferative neoplasms (MPN) are a group of blood cancers that boost normal blood cell production in the bone marrow. Abnormal mutations in stem cells were found accompanying with the occurrence of MPN. ...

    Chunjie Yu, Qiong Yang, Yuhong Chen, Demin Wang, Ross Levine, John Crispino, Qiang Wen and Zan Huang

    Cell & Bioscience 2016 6:34

    Published on: 23 May 2016

  16. Research

    Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

    Excessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on ...

    Jiaqi Liu, Jichao Wu, Aili Sun, Yu Sun, Xiangjing Yu, Ning Liu, Shiyun Dong, Fan Yang, Linxue Zhang, Xin Zhong, Changqing Xu, Fanghao Lu and Weihua Zhang

    Cell & Bioscience 2016 6:33

    Published on: 23 May 2016

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