Fig. 4

Role of m6A modification-mediated autophagy in hepatocellular carcinoma and lung cancer, m6a modification influences the expression of ATG genes or regulatory proteins that are upstream of autophagy. This regulates the levels of autophagy and impacts the progression of tumors. In the case of hepatocellular carcinoma, m6a modification affects the expression of specific target genes such as ATG14, ATG2A, LKB1, and FOXO3, thereby influencing the level of autophagy and the progression of the disease. Similarly, in lung cancer, m6a modification affects the expression of target genes like DCP2, ATG5, ATG7, and also influences the stability of LncRNA GAS5 and LncRNA MALAT1. These changes in gene expression and stability subsequently regulate autophagy and impact the progression of lung cancer