Fig. 2From: Cellular and molecular mechanisms of aspartoacylase and its role in Canavan diseaseThe active site. A zoom in on the active site within one subunit of the human ASPA structure (PDB: 2O53) [44] and residues (H21, E24, H116) coordinating the Zn2+ ion (red). Residues Arg63, Asn70, Arg71, Arg168, and Tyr288 interact with the substrateBack to article page