Fig. 4
From: The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
Potential mechanisms by which SRC-1 promotes breast cancer progression. The transactivation of ER is dependent on leucine-rich motifs, which constitute the ligand-regulated binding site of SRC-1. ER can interact with SRC-1 to modulate the expression of genes central to breast cancer progression. The transcriptional activity of several transcription factors, including HOXC11, PEA3, AP-1, HIF1α, c-FOS, Ets1/2, and STAT1/3, can be increased by SRC-1. Their target genes have various biological activities, such as promotion of tumour proliferation, metastasis, or angiogenesis