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Fig. 1 | Cell & Bioscience

Fig. 1

From: Unveiling the functional heterogeneity of cytokine-primed human umbilical cord mesenchymal stem cells through single-cell RNA sequencing

Fig. 1

Cellular heterogeneity of hUC-MSCs before and after cytokine priming (A) Schematic overview of the study design. (B) t-SNE plots of the scRNA-seq clusters of hUC-MSCs. (C) t-SNE plots showing the expression levels of marker genes of hUC-MSCs. (D) Violin plots showing the expression levels of the receptor genes IFN-γ (IFNGR1, IFNGR2), TNF-α (TNFRSF1A, TNFRSF1B), IL-4 (IL4R), IL-6 (IL6R), IL-15 (IL15RA), and IL-17 (IL17RA, IL17RC, IL17RD). (E) t-SNE plots of the scRNA-seq data of hUC-MSCs after cytokine priming. (F) Sector graph illustrating the percentage change in the four clusters in unprimed, IFN-γ-primed, or TNF-α-primed hUC-MSCs; this change reflects the change in heterogeneity of the cell subpopulations. (G) Violin plots showing the expression levels of the marker genes of hUC-MSCs after cytokine priming

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Cell & Bioscience

ISSN: 2045-3701

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