Table 3 Anti-angiogenic lncRNAs
From: The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
lncRNAs | Regulation in Disease Models | Function | Mechanism | Refs |
|---|---|---|---|---|
MEG3 | Downregulated in diabetic and DR serum, STZ-induced diabetic mice, HG-treated RECs | Alleviates retinal vascular dysfunction | Represses angiogenesis by acting as ceRNA for miR-6720-5p that targets CYB5R2, ceRNA for miR-9, and by inhibiting TGF-β and VEGF expression | |
PKNY | Decreased by hypoxia in RECs and in the RPE/choroid of the laser-induced CNV model | Inhibits choroid sprouting angiogenesis and laser-induced CNV | Represses angiogenesis by interacting with PTBP1, and acting as ceRNA for miR-124 that targets pro-apoptotic BIM gene | [120] |