Fig. 8

MALAT1 lncRNA promotes angiogenesis by acting as ceRNA for miR203a-3p, miR-205-5p, miR-124-3p, and miR-320 that target VEGF, HIF1α and EGR1, and promotes inflammation by elevating IL-1β, IL-6 and TNF-α levels. The target sequences in HIF1α that is complementary to miR-320a and miR-203a seed region are AGCUUU (1846–1852) and AUUUCA (995–1001) in HIF1α 3’UTR. The target sequences in VEGFA that is complementary to miR-205-5p and miR-203-3p seed regions are AUGAAGG (167–173) and AUUUCA (1320–1326) in VEGFA 3’UTR. The target sequence in EGR1 that is complementary to miR-124-3p seed region is GUGCCUU (769–775) in EGR1 3’UTR