Fig. 6
From: The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
H19 lncRNA Inhibits endMT by inhibiting TGF-β1 and MAPK-ERK1/2 pathway; inhibits inflammation by sponging miR-19b that targets SIRT1; enhances angiogenesis by sponging miR-29c that targets VEGF-A. The target sequence in SIRT1 that is complementary to miR-19-3p seed region is UUGCAC (1285–1291) in SIRT1 3’UTR. The target sequence in VEGFA that is complementary to miR-29c seed region is UGGUGCUA (1758–1765) in VEGFA 3’UTR