Fig. 11

TUG lncRNA enhances angiogenesis by acting as ceRNA for miR-34a-5p and miR-299 that targets VEGF, miR-204-5p that targets JAK2, miR-145-5p that targets CCN1 and miR-29c-3p that targets PDGF-BB. It also promotes inflammation by elevating TNF-α, IL-1β and IL-6. The target sequences in VEGFA that is complementary to miR-34-5p and miR-299-3p seed regions are CACUGCC (859–865) and CCCACAU in VEGFA 3’UTR. The target sequence in JAK2 that is complementary to miR-204-5p seed region is AAGGGA (1453–1459) in JAK2 3’UTR. The target sequence in CCN1 that is complementary to miR-145-5p seed region is ACUGGA (572–577) in CCN1 3’UTR. The target sequence in PDGFB that is complementary to miR-29c-3p seed region is UGGUGCU (132–138) in PDGFB 3’UTR