Fig. 10
From: The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
NEAT1 lncRNA enhances angiogenesis by acting as ceRNA for miR-19-5p that targets TGB-βR2 and therefore enhancing VEGF-A expression. It also prevents resolving inflammation by inhibiting M2 macrophage polarization by acting ceRNA for miRNA-148a-3p that targets PTEN. The target sequences in PTEN that is complementary to miR-148-3p seed region are UGCACUG (2254–2260) and UGCACUG (3151–3158) in PTEN 3’UTR. The target sequence in TGF-βR2 that is complementary to miR-17-5p seed region is GCACUUU (268–275) in TGF-βR2 3’UTR