Fig. 1
From: The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
Nuclear Mechanisms of lncRNAs. Scaffold lncRNA can serve as a structural scaffold for histone or DNA modification enzymes to regulate target gene transcription. Decoy lncRNA can act as decoy by sequestering transcription factor away from its promoter region. Guide lncRNA can guide transcription factor to its promoter region by binding to both DNA and the transcription factor. Signal lncRNAs can be induced by signals or stressors and attract transcription factors to its target gene promoter region