Fig. 4
From: RNA editing enzymes: structure, biological functions and applications
Structural features and catalytic mechanism of ADATs. A Organization of domains in ADAT family proteins. B The structures of core domain of human ADATs. The structure of ADAT1 is derived from Alpha fold, while the PDB number of ADAT2 and ADAT3 is 8AW3. C Deamination of adenosine at position 34 (wobble position) of tRNA, catalyzed by ADAT2 and ADAT3. ADAT3 has a core domain similar to ADAT2, but lacks a proton donor and thus has no catalytic activity. D Inosine 34 locates in the wobble position, which can pair with cytidine, uridine, or adenosine (base pairs ability: C > U > A)