Fig. 3
From: RNA editing enzymes: structure, biological functions and applications
Structural characterization and catalytic mechanism of cytosine deaminase. A Organization of domains in cytosine deaminases. B The structure of core deaminase domains. (APOBEC1 PBD: 6 × 91, APOBEC3A PDB: 5KEG and APOBEC3G PDB: 6BUX) C The deaminase function of APOBEC1 depends on its binding to RBM47 or A1CF, while APOBEC3A and APOBEC3G can directly catalyze the C-to-U reaction with deaminase activities. RBM47, RBM4RNA binding motif 47; A1CF, Apobec1 complementation factor