Fig. 1
From: RNA editing enzymes: structure, biological functions and applications
Structural characterization and catalytic mechanism of RNA adenosine deaminase. A Organization of domains in ADAR family proteins. B The deaminase domains of ADAR1 and ADAR2 are structurally similar. (PDB: 8E4X). C Schematic representation of the mechanism of ADARs catalyzed deaminase. Removal of the C6 amino group allows inosine to base pair with cytosine. Zα, Z-RNA binding domain; NES, nuclear export signal; NLS, nuclear localization signal