Fig. 1

High expression of PSMD7 is associated with poor prognosis in PC. (A) Expression of PSMD7 in pancreatic non-tumour tissues (n = 171) and PC patient specimens (n = 179) evaluated via the GEPIA webtool. (B) and (C) Overall survival ( p = 0.0095) and disease-free survival ( p = 0.0027) times of patients with low versus high expression of PSMD7 in PC. (D) GSEA outcomes were graphed to show the association between poorly regulated genes and PSMD7 expression in PC. (E) and (F) Western blotting and qRT-PCR assay of PSMD7 expression in human PC tissues (n = 70), together with neighbouring normal tissues (n = 70). G, Quantification and representative immunohistochemistry (IHC) images of PSMD7 expression in human PC tissues, together with neighbouring normal tissues. (H) and (I) Kaplan–Meier analysis of the overall survival ( p = 0.0117) and disease-free survival ( p = 0.0206) time of PC patients with various PSMD7 expression. (J) and (K) The PSMD7 expression in BxPC-3, AsPC-1, HPDEC, CFPAC-1, PANC-1, and SW 1990 cells analysed via qRT-PCR and western blotting. *p < 0.05, **p < 0.01