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Fig. 6 | Cell & Bioscience

Fig. 6

From: Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier

Fig. 6

IPA Analysis Results for Goblet Cell-Specific Differential Gene Expressions for (A) Compensated vs Healthy Control, (B) Early Decompensated vs Healthy Control and (C) Advanced Decompensated vs Healthy Control. The pathway maps show the potential interactions between major transcription factors, pathways, and biological functions that were differentially expressed or predicted to be regulated. Orange represents upregulation and blue represents downregulation. The goblet cells from all cirrhosis patients notably exhibited lower EIF2 signalling levels and higher expressions of the transcription factor FOXO3. Higher expressions of multiple IRFs (interferon regulatory factor) were detected in the advanced decompensated patient (C)

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Cell & Bioscience

ISSN: 2045-3701

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