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Fig. 4 | Cell & Bioscience

Fig. 4

From: Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification

Fig. 4

The secondary structure and X-ray scattering properties of recombinant α-synuclein fibrils dispersed in a buffer solution at a concentration of 1 wt.%. a The amide I region of the ATR-FTIR spectrum is analyzed, and the secondary structures in this region are deconvoluted using peak analysis. b The WAXS profile of 1 wt.% α-synuclein fibrils, dispersed in the buffer solution and exposed to X-rays for a total of 2 h. The denoised spectrum is depicted by the red curve, obtained through wavelet denoising as described in the reference [100]. c The 1D SAXS profile of the 1 wt.% α-synuclein fibrillar dispersion. The fibrils are modeled as elliptical cylinders with delta distribution, and the calculated model scattering curve is displayed as the fit. d The pair distance distribution function, p(r), of α-synuclein fibrils is illustrated

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Cell & Bioscience

ISSN: 2045-3701

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