Fig. 2

Regulatory mechanisms involved in PFKFB3

There are various regulatory mechanisms through which PFKFB3 is involved in neovascular eye diseases, and it plays a vital role in this process. This protein is involved in the differentiation of ECs, the formation of pseudopodia during physiological angiogenesis, the promotion of vascular sprouting, and the regulation of vascular barrier function during physiological angiogenesis. By reducing PFKFB3, pathological neovascularization in the eye can be inhibited. This could be achieved by targeting PFKFB3. In addition, PFKB3 has the ability to control the activation of glial cells as well as the secretion of inflammatory factors, and it contributes to various mechanisms, such as oxidative stress injury, endoMT, cell cycle regulation, and apoptosis. The figure was created using Biorender (https://www.biorender.com/)