Fig. 1
From: Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives
Workflow of TWAS in CD. The initial stage of TWAS design should consider characteristics of CD such as disease behavior, disease location, and disease status, and select GWAS datasets and eQTL populations with specific CD subtypes to ensure homogeneity within studies. TWAS could choose the public eQTL database or establish an original eQTL. The large-scale genotype dataset is used to predict expression data by eQTL to associated with CD related outcomes. CD Crohn’s disease, TWAS transcriptome-wide association studies, SNP single nucleotide polymorphism, eQTL expression quantitative trait loci