Fig. 6
From: XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Effects of Sotagliflozin and Rapamycin on the CHIR-ALI culture. (A) Representative Western blot (WB) gel of SGLT1, BiP, p-IRE1α, IRE1α and XBP1s in the CHIR-ALI cells treated with different combinations of Sota and Rapamycin (Rapa). (B) Quantification of WB data of SGLT1, BiP, IRE1α and XBP1s in the CHIR-ALI cells treated with different combinations of Sota and Rapamycin (Rapa). (C) qRT-PCR of SLC5A1, HSPA5, ERN1 and XBP1 in the CHIR-ALI cells treated with different combinations of Sota and Rapamycin (Rapa). Control (the leftmost bar in each panel) are ALI-no-CHIR cells without Sota or Rapa supplementation to the culture medium. ns: not statistically different among these three groups