Fig. 5
From: XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Sotagliflozin attenuates ER stress in CFBE cells. (A) Representative Western blot gel of SGLT1, BiP, p-IRE1α, IRE1α, and XBP1s in the CFBE-WT cells and the CFBE-dF cells treated with or without Sotagliflozin (Sota). (B) Quantification of WB data of SGLT1, BiP, p-IRE1α, IRE1α and XBP1s in the CFBE-WT cells and the CFBE-dF cells treated with or without Sotagliflozin. (C) RT-PCR of SLC5A1, HSPA5, ERN1, and XBP1 in the CFBE-WT cells and the CFBE-dF cells treated with or without Sota. (D) Immunofluorescence staining of SGLT1 in the CFBE-WT cells and the CFBE-dF cells treated with or without Sota. Scale bar: 20 μm