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Fig. 8 | Cell & Bioscience

Fig. 8

From: Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion

Fig. 8

Model of PVRL4-mediated restriction of viral infection. Viral infection elicits the IFN-I response in host cells. And IFN-I binds to the IFNAR1/IFNAR2 heterodimers, subsequently activates a series of signaling pathways to induce the expression of PVRL4. As an ISG, PVRL4 protein broadly restricts growth of enveloped RNA and DNA viruses, including VSV, HSV-1, IAV and SARS-CoV-2, by inhibiting viral entry through blocking viral-cellular membrane fusion

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Cell & Bioscience

ISSN: 2045-3701

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