Fig. 7From: Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activationThe proposed mechanism shows that AKR1A1 functions in a liver-protective manner after extended alcohol drinking by lowering the accumulation of acetaldehyde and 4-HNE in hepatocytesBack to article page