Fig. 7
Impact of BBR on bile acid homeostasis in Mdr2−/− mice. Serum and liver tissues were processed for bile acids (BA) analysis using liquid chromatography-tandem mass spectrometry (LC–MS/MS). a BA composition profile in the serum, expressed as a percentage of total BA. b Total BA, total primary BA, the ratio of primary conjugated BA to primary unconjugated BA, and TCA in the serum. c BA composition profile in the liver, expressed as a percentage of total BA. d Total BA, total primary BA, total conjugated BA, and TCA in the liver. Data are expressed as the mean ± SEM. Statistical significance relative to control: *p < 0.05, **p < 0.01 (n = 9–12)