Fig. 1

Effect of BBR on cholestatic liver injury in Mdr2^−/− mice. Mdr2^−/− mice (FVB background, both sexes) were treated with vehicle (Control group) or BBR (50 mg/kg) (BBR group) via oral gavage daily for 8 weeks. a Representative liver images. b The ratio of liver weight to body weight. c Serum liver enzyme levels (AST, ALT, ALP). d Representative images of the liver sections stained with H&E staining (scale bar, 50 µm for 20 × , 20 µm for 40 × magnification). Data are expressed as the mean ± SEM. Statistical significance relative to control: *p < 0.05, **p < 0.01 (n = 9–12)