Fig. 3
From: METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis
METTL3 depletion inhibits metastatic potential of lung cancer cells in vivo. (A) Macroscopic image of mouse lungs injected with NC-METTL3 cells and KO-METTL3 cells via the tail vein. The NC-METTL3 group exhibited a significantly higher number of metastatic tumours than the KO-METTL3 group. (B) Histological sections of mouse lungs with HE staining. The NC-METTL3 group showed a significantly higher number of metastatic noduless than the KO-METTL3 group. (C) Quantification of lung metastatic nodules in mice from the NC-METTL3 group and the KO-METTL3 group. The NC-METTL3 group demonstrated significantly more lung metastatic tumours than the KO-METTL3 group. (D) Kaplan‒Meier survival curves for the KO-NC group and KO-METTL3 group